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Discussion (42 Comments)Read Original on HackerNews
To save HN a search: a stable isotope used as a neutron capture target, to produce lutetium-177[i], used in targeted radioligand therapies[ii]. Discussed once on HN[iii].
[i] https://isotopes.gov/Ytterbium-176_is_Available_Now
[ii] https://en.wikipedia.org/wiki/Lutetium_(177Lu)_vipivotide_te...
[iii] https://news.ycombinator.com/item?id=40690196 ("Radioactive drugs strike cancer with precision (knowablemagazine.org)")
https://en.wikipedia.org/wiki/Calutron
What has changed here to make them competitive again? Or are they counting on selling small quantities at close to any cost for R&D reactors?
Speaking of which, whatever happened to laser enrichment? That was apparently very promising at some point?
>"A centrifuge plant does one thing, costs billions, and takes years to stand up. Our machines cost a few hundred thousand dollars, produce material within months, deploy anywhere, and are able to be reconfigured in a matter of days to separate various isotopes as they are needed," said Robert Mendelsohn, co-founder and CTO of Actinide.
https://en.wikipedia.org/wiki/Separation_of_isotopes_by_lase...
So calutrons will always be less energy efficient than centrifuges, but if the capital cost and construction time is low enough, calutrons might still be economically viable.
https://gruhn.me/blog/2026-08-03/
The other thing is that for a nuclear reactor, you need many kilograms of uranium. But for a Pluvicto patient, you need less than a gram of ytterbium.
Anyways, I didn't mean to downplay it.
Calutrons are using the same principle of separating ions by their mass/charge ratio, just in a preparative scale (you want to collect what is separated) rather than analytical (you just want to know how much of what).
If your images are AI, I'm assuming your text is too. But even if it's not... if you're not willing to put in the time & effort to make the images on your homepage look good, my expectations go way down.
https://www.globenewswire.com/news-release/2026/08/26/335139...
It's not that difficult from an engineering perspective, the tech is almost a century old. It's just that we will drop bombs on anyone who tries.
Nuclear nonproliferation relies on active enforcement.
low-enrichment (~20%) is what's happening here.
the bad stuff, for nukes, is ~90% enrichment.
https://en.wikipedia.org/wiki/Separative_work_units
With Texas, I'm not so sure...
Private enterprise enriching uranium is a seriously worrying development...
[0] https://www.energy.gov/ne/articles/what-high-assay-low-enric... [1] https://en.wikipedia.org/wiki/Enriched_uranium
Or seriously exciting. We might actually get affordable, clean nuclear energy this century.
https://urencousa.com/about/our-history
The parent Urenco company has been operating private uranium enrichment plants in Europe since the 1970s.
https://en.wikipedia.org/wiki/Pantex
We could reach Lex Luther level villainy in no time at all