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#shingles#vaccine#dementia#health#more#chickenpox#don#against#article#getting

Discussion (46 Comments)Read Original on HackerNews

robot_jesus•about 1 hour ago
I'm in my 40s with genetic predisposition for Alzheimer's. Been seriously considering the past year or two paying out of pocket for Shingrix. I think it would be ~$500 total for two doses.

Sure, I could wait 7 or 8 years until I qualify via insurance, but is that really worth the risk for what is an easily absorbed cost to me? Especially when I have a friend in her late 30s who just went through a very rough bout of shingles?

It makes sense to have targets like age 50 for population-wide public health recommendations. But it can and does infect people of much earlier ages.

Recent articles like this make me think I'll go ahead.

copperx•about 1 hour ago
Shingles terrifies me because it can cause hearing loss. I spoke to my GP and he wouldn't give me a script for it even though I'm 3 years away from qualifying. He mentioned side effects.
jyounker•11 minutes ago
That seems like being penny wise and pound foolish.
cyanydeez•about 1 hour ago
aside from age ranges being the tested population, your just gambling no other interference pattern is involved.
robot_jesus•about 1 hour ago
sowbug•about 1 hour ago
Shingles vaccine, if you don't feel like clicking through.
blooalien•about 1 hour ago
Thank you.
antaviana•23 minutes ago
So if you had shingles in your youth then you are better protected against dementia?
tptacek•16 minutes ago
No, the opposite. If you've had shingles before, you're more likely to get it again later, not less.
dymk•17 minutes ago
The article says that one possible reason the vaccine protects against dementia is incidental protection from other diseases. Getting chickenpox as a kid might protect you against shingles, but maybe not against those other diseases.
tptacek•15 minutes ago
No! The opposite thing is true. Getting chickenpox as a kid drastically increases your likelihood of getting shingles as an adult. The initial chickenpox infection is the mechanism by which you're set up for shingles: you get it, fight it back, and it remains dormant in your nerves. Shingles is not simply chickenpox; it's the secondary infection you get from a resurgent zoster outbreak based in your nerves.

Don't get chickenpox.

therein•15 minutes ago
Not really, shingles is a lifetime infection. You'd be more likely.
hereme888•about 1 hour ago
Replicated association, which is strong, but not proof. Initial study saw a 3.5% absolute reduction in dementia diagnoses over seven years with a very wide confidence interval. In Australia the study was replicated with 1.8% absolute reduction over 7.4 yrs. Canadian replication: 2% over 5.5 yrs.

Infections generally increase the risk of future dementia. Like the more colds you have throughout life.

gruez•about 1 hour ago
>Replicated association [...]

"association" undersells it a bit, because the data is better than the typical cohort study, which has issues like "what if people who got the vaccine are also richer and care about their health more?". There's quasi-randomization going on. From the more in depth article that's linked:

>Research is also revealing unexpected interventions that help to keep ageing minds sharp. One of the most promising derives from an analysis by Pascal Geldsetzer of Stanford University and his team of a natural experiment in Wales. In 2013 the British region started offering people aged 70-79 free vaccinations through the public-health system. This change resembled an RCT, in that a large number of people were separated almost at random into two groups: those who had already turned 80 in the weeks before the programme started, and so were not eligible to be jabbed; and those who turned 80 in the weeks after, roughly half of whom were duly vaccinated.

khriss•19 minutes ago
Recently, even the TDAP (Tetanus) vaccine was correlated with lower incidence of dementia https://news.ycombinator.com/item?id=26919881

I recall seeing a few discussions on HN comments hypothesizing that immune system stimulation via the vaccine might be the root cause. Now that the Amyloid hypothesis is on the wane, hopefully we'll explore other paths.

zahlman•18 minutes ago
> the Amyloid hypothesis is on the wane

Oh? What did I miss?

syntaxing•about 1 hour ago
I know quite a few people who got shingles in their early 20s. One of their doctors didn’t believe she had shingles until the blisters formed. The vaccine can definitely help those younger than 50, dementia benefits or not. Some of them have permanent nerve damage after getting shingles.
satya71•about 1 hour ago
TL;DR Shingles vaccines reduces chances of dementia by 20%. Yet, most countries health systems only look at the upfront cost of ~$300 and don’t recommend for all who could benefit.
MASNeo•about 1 hour ago
In a separate article the other factors are quoted with similar impact (listed in order of max potential magnitude) - anti depression treatment - education increases - hearing improvement - obesity reduction - low alcohol

The earlier you start the better.

gruez•about 1 hour ago
>anti depression treatment - regular exercise - obesity reduction - education - less/no alcohol

Injecting people with a shingles vaccine is far easier than the others you listed, which is why it stands out.

SoftTalker•about 1 hour ago
20% of what?
swed420•about 1 hour ago
CTRL+F covid: 0 results

Very shortsighted article in that regard, but that's the new normal.

If people are concerned about brain health, they'd be wise to continue a zero-covid lifestyle into 2026 and beyond, since each re-infection (which vaccines don't prevent) increases the risk of severe health outcomes, including brain-related issues among lots of others. Adding to the confusion, 40% of COVID infections are asymptomatic but carry the same longterm risks.

Yet I only see about .5-1% of the population in my area these days wearing any kind of mask/N95 respirator in public.

Fortunately at least a tiny minority are waking up to this fact, as can be seen by constant growth in communities like /r/zerocovidcommunity and Google Trends data for 'zero covid'.

xyzsparetimexyz•about 1 hour ago
Lmao